Roland Stocker Selected Research

Probucol (Lorelco)

3/2012	Succinobucol induces apoptosis in vascular smooth muscle cells.
6/2009	Molecular mechanisms underlying the antiatherosclerotic and antidiabetic effects of probucol, succinobucol, and other probucol analogues.
1/2008	Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds.
5/2007	Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice.
12/2006	Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelialization.
4/2006	Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging.
8/2005	Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice.
9/2004	Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1.
8/2002	Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits.

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Roland Stocker Research Topics

Disease

32	Atherosclerosis 10/2019 - 02/2002
21	Inflammation (Inflammations) 05/2022 - 09/2004
12	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 09/2003
7	Insulin Resistance 01/2022 - 10/2009
6	Atherosclerotic Plaque (Atheroma) 05/2022 - 07/2004
5	Coronary Artery Disease (Coronary Atherosclerosis) 03/2017 - 02/2003
5	Vascular Diseases (Vascular Disease) 10/2016 - 09/2004
5	Hyperplasia 10/2016 - 08/2003
4	Neoplasms (Cancer) 01/2019 - 10/2002
3	Infections 01/2022 - 07/2007
3	Hypotension (Low Blood Pressure) 01/2021 - 03/2010
3	Pathologic Constriction (Stenosis) 01/2019 - 12/2006
3	Rupture 01/2019 - 08/2009
3	Myocardial Infarction 03/2017 - 08/2009
3	Heart Failure 10/2015 - 02/2013
3	Malaria 07/2007 - 03/2002
2	Sepsis (Septicemia) 01/2021 - 12/2011
2	Hypoxia (Hypoxemia) 01/2021 - 04/2006
2	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2017 - 01/2016
2	Hemorrhage 01/2017 - 07/2007
2	Arteritis 01/2016 - 02/2014
2	Anemia 05/2015 - 01/2011
2	Endotoxemia 08/2013 - 03/2010
2	Skin Neoplasms (Skin Cancer) 06/2012 - 06/2012
2	Stroke (Strokes) 08/2009 - 07/2006
2	Coronary Disease (Coronary Heart Disease) 01/2009 - 10/2002
1	Infection with Mycobacterium marinum 01/2022
1	Hyperbilirubinemia 12/2021
1	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 11/2021
1	Diabetes Mellitus 11/2021
1	Metabolic Diseases (Metabolic Disease) 11/2021
1	Fatty Liver 11/2021
1	Carcinogenesis 01/2019

Drug/Important Bio-Agent (IBA)

20	AntioxidantsIBA 10/2016 - 02/2002
15	Proteins (Proteins, Gene)FDA Link 11/2018 - 02/2002
14	LipidsIBA 11/2017 - 02/2002
12	ApolipoproteinsIBA 10/2019 - 02/2002
11	Apolipoproteins E (ApoE)IBA 10/2019 - 02/2002
9	Peroxidase (Myeloperoxidase)IBA 05/2022 - 11/2004
9	Probucol (Lorelco)FDA Link 03/2012 - 08/2002
9	Vitamin E FDA LinkGeneric 01/2007 - 02/2002
8	Heme (Haem)IBA 11/2021 - 06/2007
8	Oxidants (Oxidizing Agents)IBA 11/2018 - 11/2004
8	Heme Oxygenase-1IBA 05/2015 - 04/2006
7	Tryptophan (L-Tryptophan)FDA Link 11/2021 - 09/2003
7	oxidized low density lipoproteinIBA 01/2005 - 02/2002
6	EnzymesIBA 01/2021 - 03/2009
6	Pharmaceutical PreparationsIBA 11/2017 - 05/2007
6	coenzyme Q10 (CoQ10)IBA 10/2015 - 08/2003
6	Lipoproteins (Lipoprotein)IBA 05/2007 - 08/2002
6	alpha-Tocopherol FDA Link 09/2006 - 02/2002
5	Superoxides (Superoxide)IBA 01/2022 - 10/2009
5	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 07/2006
5	CholesterolIBA 05/2007 - 08/2002
5	LDL Lipoproteins (beta Lipoproteins)IBA 10/2004 - 02/2002
4	Insulin (Novolin)FDA Link 01/2022 - 01/2018
4	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2022 - 01/2018
4	BilirubinIBA 12/2021 - 10/2016
4	KynurenineIBA 12/2011 - 03/2002
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 03/2014
3	IronIBA 01/2022 - 01/2011
3	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 11/2021 - 12/2011
3	Oxygen (Dioxygen)IBA 01/2021 - 10/2004
3	NADPH Oxidases (NAD(P)H oxidase)IBA 11/2017 - 10/2015
3	Biomarkers (Surrogate Marker)IBA 11/2017 - 01/2005
3	CytokinesIBA 02/2014 - 05/2012
3	QuercetinIBA 12/2013 - 04/2010
3	Messenger RNA (mRNA)IBA 06/2012 - 04/2012
3	Apolipoprotein A-I (Apolipoprotein A1)IBA 03/2009 - 02/2003
2	Biological ProductsIBA 01/2022 - 11/2012
2	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 01/2022 - 10/2016
2	Protein Isoforms (Isoforms)IBA 11/2021 - 11/2017
2	Triglycerides (Triacylglycerol)IBA 11/2021 - 05/2007
2	Tocopherols (Tocopherol)IBA 11/2021 - 01/2007
2	Transcription Factors (Transcription Factor)IBA 01/2021 - 12/2010
2	Mitochondrial DNA (mtDNA)IBA 01/2019 - 03/2014
2	CollagenIBA 03/2017 - 10/2015
2	UbiquinoneIBA 10/2015 - 08/2003
2	Catalytic DNA (Deoxyribozyme)IBA 06/2012 - 06/2012
2	AntibodiesIBA 06/2012 - 06/2011
2	Endothelium-Dependent Relaxing Factors (Endothelium Derived Relaxing Factor)IBA 12/2011 - 03/2010
2	Phenobarbital (Luminal)FDA Link 12/2006 - 04/2006
2	IonsIBA 10/2006 - 03/2002
2	Hypochlorous Acid (Hypochlorite)IBA 04/2005 - 03/2002
1	AnionsIBA 01/2022
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 11/2021
1	biliverdin reductaseIBA 11/2021
1	F2-Isoprostanes (F2 Isoprostanes)IBA 11/2021
1	Antisense OligonucleotidesIBA 10/2021
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 01/2021
1	Carbon MonoxideIBA 01/2021
1	Adenosine Triphosphate (ATP)IBA 01/2019
1	Mitochondrial Proton-Translocating ATPases (Mitochondrial ATP Synthase)IBA 01/2019
1	Dihydroorotate DehydrogenaseIBA 01/2019
1	CarbohydratesIBA 01/2019
1	pyrimidineIBA 01/2019
1	ParaquatIBA 11/2018
1	AMP-Activated Protein KinasesIBA 11/2018

Therapy/Procedure

6	Therapeutics 01/2017 - 07/2006
1	Oral Administration 01/2019